BrainWeb: Details on Anatomical Model of Normal Brain

Anatomical model:

Design and Construction of a Realistic Digital Brain Phantom,
DL Collins, AP Zijdenbos, V Kollokian, JG Sled, NJ Kabani, CJ Holmes and AC Evans.
IEEE Transactions on Medical Imaging, vol.17, No.3, p.463--468, June 1998.

Thick slices:

The digital brain phantom has a spatial resolution of 1mm3. For slice thicknesses larger than 1mm, a Fourier resampling technique is used to evaluate the imaging chain partial volume effect. This is a realistic simulation of what actually happens in MR imaging.

The 3mm, 5mm, 7mm, and 9mm images are derived from the original 1mm images by resampling along the Z (slice) axis only. In order to emulate a perfectly continuous phantom (instead of one discretized into blocks) the image intensity that has been recorded experimentally for each voxel is assumed to be the image intensity at the centre of each voxel. Linear interpolation is then used to join these central intensities. The resampling is achieved as an integration of this "continuous" image (this is achieved in the simulation by effectively allowing the mixture of the tissue classes to vary in a linear fashion between voxels). Finally, when the data is ordered in space the centre of the first voxel (no matter what size the voxels are) is defined to be at z = 0.

The following graph illustrates the interpolation process: